منابع مشابه
Oncogene-Induced Replication Stress Drives Genome Instability and Tumorigenesis
Genomic instability plays a key role in driving cancer development. It is already found in precancerous lesions and allows the acquisition of additional cancerous features. A major source of genomic instability in early stages of tumorigenesis is DNA replication stress. Normally, origin licensing and activation, as well as replication fork progression, are tightly regulated to allow faithful du...
متن کاملStress-induced modulators of repeat instability and genome evolution.
Evolution hinges on the ability of organisms to adapt to their environment. A key regulator of adaptability is mutation rate, which must be balanced to maintain genome fidelity while permitting sufficient plasticity to cope with environmental changes. Multiple mechanisms govern an organism's mutation rate. Constitutive mechanisms include mutator alleles that drive global, permanent increases in...
متن کاملIntercalation-Induced Stress and Heat Generation within Single Lithium-Ion Battery Cathode Particles
Intercalation-induced stress and heat generation inside Li-ion battery cathode LiMn2O4 particles under potentiodynamic control are simulated in this paper. We combined analyses of transport and kinetics in determining resulting stresses, which arise from concentration gradients in cathode particles, and heat generation. Two peaks in boundary reaction flux, and resulting stresses, were determine...
متن کاملNumerical Simulation of Intercalation-Induced Stress in Li-Ion Battery Electrode Particles
Severe, particle-level strains induced during both production and cycling have been putatively linked to lifetime limiting damage in lithium-ion cells. Because of the presently unknown contributions of manufacturing and intercalation induced stresses in Li cells, this correlation is critical in determining optimal materials and manufacturing methods for these cells. Both global and localized lo...
متن کاملChromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress.
Aneuploidy is a hallmark of human solid cancers that arises from errors in mitosis and results in gain and loss of oncogenes and tumor suppressors. Aneuploidy poses a growth disadvantage for cells grown in vitro, suggesting that cancer cells adapt to this burden. To understand better the consequences of aneuploidy in a rapidly proliferating adult tissue, we engineered a mouse in which chromosom...
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ژورنال
عنوان ژورنال: Acta Materialia
سال: 2020
ISSN: 1359-6454
DOI: 10.1016/j.actamat.2020.09.059